The Relationship between Carnitine Levels and Lipid Peroxidation in Glial Brain Tumors
نویسندگان
چکیده
Aim: It is assumed that reactive oxygen species and lipid peroxidation cause cell membrane damage and play a role in oncogenesis. Carnitine and acyl esters, which play a role in intracellular short-, medium-, and longchain fatty acid metabolism, are one of the defense mechanisms against free radical toxicity. It is thought that the protective effects of carnitine are related with its role in lipid metabolism. In our study, we analyzed the relation between malondialdehyde (MDA) and free carnitine, and C2, C3, C4, C5, C6, C8, C10, C12, C14:1, C14, C16:1, C16, C18:1, C18, C20:4 carnitine levels in glial tumors [glioblastoma multiforme (GBM) (n = 29), high-grade astrocytoma (n = 8) and low-grade astrocytoma (n = 8)] to determine whether there is a relation between carnitine-acyl carnitines and lipid peroxidation in carcinogenesis.
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